Scientists from the Pashurur Institute (France) ci After identifying the characteristics of 4 T T lymphocytes, the virus has destroyed the infected cells from the virus, which is primarily infected by the virus. The lymphocytes metabolism allows the multiplication of HIV, but the researchers have succeeded in preventing them.
Antiretroviral treatment used today is designed to prevent HIV infection, but it can not remove the virus from the body. The virus remains in the reservoir, the immune cells of CD4T lymphocytes, are the main targets of HIV. However, not all types of viruses are infected with CD4 cells and so far the cause of this phenomenon is not known.
In this study, published in the journal & # 39; Cell Metabolism& # 39; Scientists and their colleagues of HIV, Inflation and Persistence Unit in the Pasteure Institute have identified the characteristics of various 4 subtypes of CD4 associated with HIV infection.
The more they separate or experience CD4 cells, the more they need to produce energy to perform their work. Experiments have shown that it is metabolic activity of the cell, and especially its glucose consumption, which plays an important role in the sensitization of HIV infection.
Viruses mainly target cells with high metabolism. To multiply, it streamlines the energy and products provided by the cell.
This requirement creates vulnerabilities for the virus, and it can be exploited to fight against infected cells by people under the study's charge.
Scientists have already been investigated in cancer research that the inhibitor of metabolic activity managed to block the infection thanks to ex vivo.
"We have examined the former VOs that due to certain metabolic inhibitors, the virus can no longer infects the cells and amplification closes in the reservoirs of patients receiving antiretroviral treatment," he explained in his article.