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The biological clock of a parent runs faster than previously believed – 02/12/2018



The biological clock also runs for the father. And the latest research suggests that it does as quickly as we thought earlier.

If so far it was supposed to beE was 55 years old While there may be some cases of child health due to the accumulation of chromosome changes in sperm, a new study of the Stanford University School of Medicine has reported more than 40 million births, indicating that The risk starts from 35 years and is remarkable from 45.

In the father of 45 years old, he finds 14% more premature babies

Typically, Stanford scientists have claimed that Aging fathers are at risk of problems during childbirthCrushing with low weight, the need for assisted breathing or entering the neonatal intensive care unit (NICU).

Study data published in the British Medical Journal – suggests that factors like maternal, racial, education, educational level, marital status or smoking history are controlled, Once the father of 35 years of age has increased the risk at birth a little bit Because with each year, the age of man changes two in the average DNA of their sperm.

Once the father increases the risk of birth at the age of 35 years, because at the age of male, he accumulates on average two new mutations in his sperm dna each year.

Once the father increases the risk of birth at the age of 35 years, because at the age of male, he accumulates on average two new mutations in his sperm dna each year.

thus, Children born 45 years of age or older are likely to be born 14% more likelyPresenting less weight and getting into NICU; With parents aged 25 to 34 (average age of parent in the United States). Y The risk of attack increases, According to the report, 18%. Y After 50 years, the need for ventilation at birth was 10% higher, and the need for assistance in the ICU increased by 28%.

Specifically, Stanford scientists say that aging is a father, the risk is that the baby has problems at birth: the need to get rid of weight loss, assisted breathing or to enter the care unit. Neonatal Intensive Care (NICU).

Rafael Oliva, a UB professor and advisor to the Clinical Biomedical Diagnostic Center, is not surprised by this conclusion, the researcher's head, research group at Molecular Biology of Epigenetics and Epigenomics Expert in Spimetozoa and reproductive of Idiapes. "It's an interesting job And it goes according to the other checks: The role of father in the womb and son's health is more important than consideration and it is also a male biological clock. "

An elderly father, a baby is more likely to have problems during birth, as a new study states.

An elderly father, a baby is more likely to have problems during birth, as a new study states.

Julio Herrera, head of the supported breeding of Val de Hebron, also believes that this study is related Draws attention to one factor – the age of the male parent – which is not usually taken into consideration Because it was believed that there was some influence on it and 55 years later. However, it takes into account that the concrete results of the investigation should be taken with caution because it is the last observable study that doctors or parents have filled with 40 million born forms, which group the mother. Age is too broad that evaluating the risks of birth at birth due to the father will not affect the age of the couple or the first child for the woman or not. "The important thing is that it focuses on the need to study the events of the biological clock and age of the parent More deeply, but it is possible and needs to be taken as young couples in the control group of older parents with young mothers, "Harrorov says.

Allergists, responsible for the Devyears mail unit, agree that it is difficult to study in major cases, which does not have specific bias, although it admits that they have more changes on the chromosome level as a man's age. And may cause problems in the fetus. "In fact, in Catalan public health, if a woman is older than 38 or a person of 55 years of age, then the limit of immunization is limited," she explains. Vives believes that many reproductive centers are run by a gynecologist and focus more on the condition of women.R, "But 50% fertility is the responsibility of the person, and there are many factors and habits – poison, consumption of coffee, tea, overweight, tobacco … – which" affects the quality of the sperm and both fertility, affect the development of pregnancy. Changes may result from premature baby or respiratory problems, which show Stanford studies.

"It's an interesting job and based on what other research shows: The role of the child in the pregnancy and the role of the child's health are more important than that, and the male biological clock is also"

Rafael Oliva, an expert in epigenetics and sperm epigenetics

In a meeting of the European Society of Fertility and Pregnancy in 2017, a study was conducted by Harvard University biologists, who came to the conclusion after analyzing the treatment of Vitro Fertilization in 19000. When younger women tried to keep children with men over 40 years of age, there was a possibility of failing in pregnancy. On the other hand, the results were much better when the man did not reach his thirties.

An elderly father, a baby is more likely to have problems during birth, as a new study states.

An elderly father, a baby is more likely to have problems during birth, as a new study states.

In the field of epigenetics, Oliva explains that there is still a little bit of information in humans about everything extracted by sperm, yet in the last two years, evidence has been collected in the evidence that men's lifestyles also eat the experiences they make- The causes of measurable changes in your sperms and pass through to the next generation and sometimes up to a third. "We are used to focus on concerns about mothers because ocote is very big compared to sperm and it has long been believed that if only children have more legacy than DNA, it would be mother's mother tongue, because of cytoplasmic factors in octet, because It was believed that sperm has only DNA; but today it is very clear that sperm In the father's genome is arranged by histones and protamainsa, which gives the ability to provide epigenetic information ", idibepsana researchers summarized.

This week, a scientific journal PNAA had announced that a team of doctors in the United States has ended the belief that DNA of mitochondria – the energy that gives energy to the cells – is transmitted only by the mother – a dozen of three separate families For more people who have received mitochondria from both parents. Researchers believe that it is an exception to the general rule, which is when the Patronal Mitochondria zygote enters, there is a chemical label that marks them to destroy. However, The discovery that a person receives goes beyond the rank of a biological heritage and marks it through the impression that both life, habits and the environment have left the parents.

Source: La Vangardia


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