Saturday , February 4 2023

These medicines increase the risk of dementia by 50%.


Anticholinergics are prescription drugs for overactive bladder, depression, Parkinson's disease or brain. According to British studies, more than 55 people who take the most, they will increase the risk of dementia by almost 50%.

In France, about 900,000 people suffer Alzheimer's Disease And 200,000 new cases dementias Diagnosed every year. If age, legacy, evenHypertension, The Diabetes, Can play a role in Alzheimer's-type dementia, no wonder if some medicines promote disease.

This anticholinergics Is there Molecules Whose actions are opposedAcetylcholine, a Neurotransmitter Nervous system. These drugs have been suggested for various conditions: For lung problems, AllergyRelated problems Bladder, Gastrointestinal disorders, Parkinson's disease… but there is short-term side effects in anticholinergics, which lead to memory loss and confusion. Is there any long-term effects on it? Brain ?

To find out, researchers from the University of Newham analyzed data of more than 58,000 people Dementia, And 225,000 Witnesses. Participants aged over 55 years of age were 82 years old.

One to eleven years ago Diagnosis 57% of Dementia patients take anticoagulants compared to 51% of the control. Generally, six prescriptions for these medicines have been received compared to the four drugs that people have diagnosed with dementia. The most proposed medicines were AntidepressantsAntimusuristics for the problems of excessive bladder medications and overactive bladder problems.

Anticholinergics increase the risk of dementia

The results of the study published in the journal JAMA Internal Medicine Overall, the risk of dementia related to anticholinergic drugs is: For people who have used the most, the risk of dementia increased by 49%, which they never took.

Specifically, the drugs related to these risks were antidepressants, Antipsychotics, Drugs against Parkinson's disease, theseWii Or bladder disorders On the other hand, there is no risk involved in taking itAntihistamine Or medicines for gastrointestinal disorders.

When the disease was diagnosed at the age of 80, the relationship between Anticholinergics and Dementia was strong. If the cause-and-effect relationship is displayed, it means that about 10% of the diagnosed dentures in the UK are due to anticoagulinis! Studies suggest that these medicines should be cautious with intermediate and old people.

a University Press ReleasesTom Denning, who took part in this work, explained that, despite these risks, "It is important that patients taking such medicines will not stop them suddenly, because this can be more harmful. If the patients are concerned, they should discuss with their doctor to discuss the benefits and disadvantages of the treatment they receive."

Do remember

  • Anticholinergics, in many cases, have been prescribed medicines: Parkinson's, Depression, Brain, Allergies, Imbalances …
  • They have short-term side effects with memory loss.
  • Some anticoagulants increase the risk of dementia in the long run.

Drugs that start the Alzheimer's

Insarm article was published on February 16, 2006

Potentially anti-collagenic drugs can affect elderly due to moderate cognitive (or intellectual) abnormalities, especially reaction time, immediate or delayed memory or language. The conclusion is that Ritchie and his team (Insarm Research Team 361 " Diseases Nervous System: Epidemiology and Medical Research ", Montpellier).

Details of these results are published by online British Medical Journal.

Anti-colinergic drugs in old age are usually suggested for the treatment of diseases such as urinary imbalances, Parkinson's disease or specific psychiatric disorder. These compounds, some of which may be available without prescription, are potentially inhibited by the transmission of chemical or neurotransmitter messages in the brain, such asAcetylcholine, Especially involved in memory or teaching.

Mary-Lower Anselin and Sylvia Artero on Karen Ritchie's team followed 37 years of age with dementia at the age of 60. These people were asked about their current health problems, past and drug use. His intellectual performance has also been scrutinized.

About 10% of the defendants in this sample took anti-colling drugs for at least one year. Drug users had poor cognitive abilities compared to non-users. Eight percent had moderate intellectual impairment (compared to 35% in inefficient group).

Anticonligenics is a key contributing factor in the prediction of cognitive changes. Actually, taking into account the other Risk Factors Famous cognitive impairment (age, gender, education level, hypertension), 5 times the number of people with risk of waste in cognitive abilities. On the other hand, with an 8-year decline in analyzes, users do not see significant differences in the risk of dementia development and non-users of anticholinergics.

After giving these results the researchers have estimated thatIt is important that the prescribers of these drugs be warned of their possible side effects.

In addition, the authors show absurd situations that can lead to poor results of these results. Indeed, the identity of change in cognitive abilities often abandons suspicion of early dementia, and thus stimulates the doctor in the treatment of this dementia. In this case, people with moderate anticoagulant disabilities will be given pro-colinogensive medicines to respond to the effects of anti-cholinurgicis.

According to the conclusion, the researchers suggest that the medicines determine the condition of an older person before considering treatment for old age, which has a moderate error in intellectual capacity (whether they use anticoagenetics) or not.

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