Tuesday , October 26 2021

Understand chrypat: DNA-editing technology that can make HIV-resistant children Science and health



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Anxiety exists from the beginning. Since Crisil came six years ago, scientific journals and international organizations are thoughtful: Can we edit human DNA? We are talking about an atom that has existed for thousands, thousands of years. What will be the limits of genetic editing? That's a critical moral question.

On the other hand, DNA editing techniques are simple and affordable. However, what it can do, it is a revolution, because it is a reputable scientific journal "Science" on one of its wraps. According to the Chinese scientist's announcement, we can raise HIV-resistant children. We can actually edit the genetic material of any living thing. Expectations revolve around treating important diseases such as alzheimer's and cancer.

Understand what is Crispray

Understand what is Crispray

Scientists upgraded Krisp Technique for practical use in 2012, but it was "Bombay" in 2015. It was used in human embryonic genomes for the development of extramascular dogs, non-viral hogs, anti-allergenic peanuts and kit-resistant wheat.

Using the enzyme present in the bacterial defense system. Researchers use Case 9 with "guide" RNA to "trim" an interested part in DNA.

Understand Chrisiph - Photo: Beta Javarsky / G1Understand Chrisiph - Photo: Beta Javarsky / G1

Understand Chrisiph – Photo: Beta Javarsky / G1

Among all this, ChrisPray is cited as a prospect of future Nobel. One issue that needs to be addressed – The decision taken last year – The authorship of this search was: Three scientists, two women and one man took the right to a United States jurisdiction to make a decision.

Patent is worth millions of dollars. On one hand, two women are often cited for the Nobel Prize: Berlin Institute Max Planck's Microbiologist Emanuel Cherpentier; And Jennifer Dowden, a biochemist at the University of California at Berkeley. On the other hand, a research institute affiliated with Fang Zhang, Harvard University and MIT of Broad Institute

In February 2017, Zhang won the war. It has the right to benefit from using the technology.

Fang Zhang, Broad Institute - Photo: Stan Grassier / Broad InstituteFang Zhang, Broad Institute - Photo: Stan Grassier / Broad Institute

Fang Zhang, Broad Institute – Photo: Stan Grassier / Broad Institute

Chinese researcher Hey Gianqi said that he has made genetically educated infants in the world. These different girls – Lulu and Nana – are born this month.

There is no scientific confirmation of their feats yet. He did not publish scientific articles in journals, neither reputable nor unfamiliar. He did not disclose the names included.

Chinese scientific scientist, Gianquei has claimed that she has helped create the world's first genetically modified children. Photo: Mark Shifelben (AP)Chinese scientific scientist, Gianquei has claimed that she has helped create the world's first genetically modified children. Photo: Mark Shifelben (AP)

Chinese scientific scientist, Gianquei has claimed that she has helped create the world's first genetically modified children. Photo: Mark Shifelben (AP)

At the beginning of the lesson: can we edit parmanus where it took millions of years where it is?

Whether they are doing research, we take a long way.

In August 2017, nature was first published for the disorder of genital herpes in human embryos to prevent inherited heart conditions. This research generated healthy illusions, which would develop from neutral cardiomopas without genetic editing – a disease that makes blood difficult to pump through the heart.

In April 2016, the Journal of "Cell Reports" was evaluated that this change requires adjustment to avoid the action of AIDS virus, which has high potential for change. A year later, in May 2017, Molecular Therapy Magazine reported that scientists at the University of Texas in Philadelphia could edit the code and prevent the virus from replicating in animals.

Chinese made the first injection of human genes edited with ChrisPray in October 2016. A team from Sichuan University incorporated modified cells into aggressive type of lung cancer – the protein was disabled by using clippings. DNA, which is used only for the spread of cancer.

Human orbits were first modified with new technology for genetic editing, different from known CRISPR (used in the above image) - Photo: OHSUHuman orbits were first modified with new technology for genetic editing, different from known CRISPR (used in the above image) - Photo: OHSU

Human orbits were first modified with new technology for genetic editing, different from known CRISPR (used in the above image) – Photo: OHSU

In the United States, scientists have made human organs in transplants to transplant. This is done in two steps: First of all, experts remove the gene from the new fertilized swine uterus, which leads to the development of the pancreas. Then, human stem cells enter the animal's embryo. With this, the human organ develops inside the pig and can then be pulled back for potential surgery.

United States and China: Acting internationally, or consensus on the use of at least one of the countries in the research that works best in research. Thus, scientists will be able to grow more and more on this topic.

O G1 Indicates that the announcement of Chinese who acquired children's DNA is due to the opposition of scientists around the world. According to experts, it has harmed morality, laws, safety and has precarious results. He also said that his university at Gianikui said that he will investigate the case. According to the organization, this case is a serious violation of "morality and educational standards."

In the United States, the FDA, the country "Anwasa", hinders the development of some research. In March this year, the agency closed the first human tests with the Crisps.

He left the United States because, of course, genetic editing is not allowed with the application in humans, except laboratory research, interference without life or permanent realization. China prohibits human cloning, but not specifically the acquisition of jeans.

US The concerns of regulators have been well established: "Nature biotechnology has questioned Crisp's accuracy and has shown that laboratory experiments using mouse and human cells show that this technology produces" frequent "comprehensive" genetic mutations ".

According to researchers, "DNA changes have previously been predicted less seriously."

A possible "savior" of Crisil could increase the risk of cancer by using an editing technique published in "Nature Medicine" in June this year. According to scientists, in this version there will be a tendency to choose important cells without proteins to prevent carcinogenic mechanisms.

And among all those organizations, such as the FDA, which can determine the barrier in all the research, there is an "egg or chicken" dilemma: should we continue with research to understand the risks and determine the threshold, or we can set limits and Continue research without risk?

It is an answer that needs to be discussed in the coming years even before future children come around.

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