Thursday , October 21 2021

Rice professor's role in 'world's first gene-edited babies' under investigation



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"This research raises troubling scientific, legal and ethical questions," said Doug Miller, Director of Rice University's media relations team. In a statement, Miller said Rice had "no knowledge of this work."

He claims that he used a tool called CRISPR-Cas9, which can insert or deactivate certain genes, to alter the DNA of several embryos to make them resistant to HIV.

Two babies, twin girls named Lulu and Nana, were supposedly born a "few weeks ago," He announced in a video on YouTube, saying they were "as healthy as any other babies" and were home with their parents, Grace and Mark.
He is scheduled to present his work on the Second International Summit on Human Genome
Chinese scientist claims world's first gene-edited babies, amid denial from hospital and international outcry
Worldwide response to Swift Hundreds of Chinese biomedical and AIDS researchers issued statements condemning the research. Several scientists said the experiment was "monstrous," "premature, dangerous and irresponsible." The Chinese government announced a "immediate investigation" to verify he's claims, questioning the ethical approval process and wondering whether the families were properly informed of the nature of the experiment.
Scientists in China breed healthy mice from two females

Deem did not respond to CNN's calls and emails but told The Associated Press that he had given consent and "absolutely" believed they were the risks.

Deem also said he holds "a small stake" and is on the scientific advisory board of He's companies.

Rice University said it did not believe that any of the clinical work performed in the United States, but "regardless of where it was conducted, this work as described in press reports, scientific conduct guidelines and is unjustified with ethical norms of the scientific community and rice university. "

While at Rice, Deem has worked extensively on influenza vaccine efficacy, immune system modulation and HIV Deem also says a research interest is the "mathematical model of evolution that accounts for cross-species genetic exchange."
A recent paper on math modeling for flu was co-written by biomedical ethics researcher Kirstin Matthews at Rice University's Baker Institute for Public Policy.

Matthews wrote in an email that she was "ashamed yesterday, like many others, to find out that Professor Deem was involved in this research." Adding that she had only recently started working with Deem, she said that she did not "see anything to suggest that Professor Deem's scientific work is in question," nor did he believe any data in the co-authored paper had affected.

"If Professor Deem informed me of his work using CRISPR on human embryos to develop a baby, I would have used extreme caution using human embryos and to wait for more data on risks before use," Matthews wrote.

According to a news release on the Rice University website, He became a graduate student under Deem in 2007 and co-written several papers "of tremendous significance" with Deem.

He, who says "the son of rice farmers in Hunan Province in China," was lead author with Deem on a paper presenting a mathematical model that could determine within two weeks whether a new strain of the influenza virus should be included in the annual seasonal flu vaccine The World Health Organization's model takes up to six months.

"Jiankui is a very high-impact student," Deem said in 2010. "He has done a fantastic job here at Rice, and I am sure he will be successful in his career."

CNN's Oscar Holland and Serenitie Wang contributed to this report.

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