Wednesday , January 27 2021

Scientists develop a 10-minute universal cancer test



Scientists have developed a universal cancer test that can detect the pathogenesis of the patient's blood stream.

In an easy and simple test, the color-changing fluid is used to reveal the presence of changing cells in the body and provide results in less than 10 minutes.

While the test is still in development, it leads to a revolutionary new approach to screening cancer, which can be a simple procedure for this disease for regular screening doctors.

Laura Carrascosa, a researcher at Queensland University, said, "The main advantage of this technology is that it is very cheap and very easy, so it can be easily adopted in the clinic."

This test has about 90% of sensitivity, which means it will detect approximately 90% of the 100 cancer cases, and 10% is false positive. It will act as an early diagnosis for cancer, doctors follow positive results with a more focused investigation.

"Our technology can be a screening tool that can be a screening tool for reporting patients who may have cancer, but they will need later tests with other technologies to identify the cancer type and stage," Karscosa said.

Through the invention of the Queensland team, the test was made that the cancer surface on the surface of the DNA And the usual DNA stick is significantly differently. Due to this, they were developed to develop the test that distinguishes between healthy cells and cancerous people, which also receives blood flow from DNA signs.

Healthy cells ensure that they work properly by patterning their DNA with atoms known as methyl groups. This work is like volume control, which is not necessary for the science of genes and others. In cancer cells, this pattern is hijacked, so that only cancer helps cancer grow. When Methyl Group is dotted in DNA of the normal cells, DNA in cancer cells is usually a bear, because methyl groups are found only in small clusters at specific locations.

Writing in a journal of Nature Communications, Queensland team described a series of tests that confirmed the pattern of breast in breast, prostate and colorectal cancer, and methyl groups in lymphoma. Then they showed that these methods have dramatically impacted on the chemistry of DNA, which are common and cancers of DNA Treats water in a very different way. Karscosa said, "This is a huge discovery that no one has ever caught."

After a series of experiments, scientists have been affected on the new test for cancer. Suspicious DNA is added to water containing small gold nanoparticles. Despite the gold being made, the particles make the water pink. If DNA is added to cancer cells, it is brought in nanoparticles so that the water retains its original color. But if DNA is added from healthy cells, DNA connects particles separately and makes the water blue. "In this test sample, cancer is very susceptible to detecting very low levels of DNA," Karscosa said.

Under the leadership of professor of chemistry at Queensland University Matt Truun, researchers have conducted 200 human cancer samples and a healthy DNA test. "We certainly do not know whether it is a sacred grail for all cancer diagnostics, but it looks really as an easy-to-be universal marker for cancer and as an accessible and affordable technology that does not require complex lab-based devices. DNA sequencing, "True said.

Scientists now work towards clinical trials with patients that have an extended range of cancer types so far tested.

To test for today's cancer, doctors must collect the tissue biopsy from the patient's suspected tumor. The procedure is aggressive and depends on the patient considering the patient, or their GP. Reveals the symptoms identified as a possible symptom of cancer. A less aggressive test that previously has the potential to spot cancer can change how patients are diagnosed.

DNA in cancer cells can be stimulated with mutation that operates specific tumor growth, but these changes vary depending on the type of cancer. A universal cancer test is not specific enough to direct the location or size of the tumor, but the doctors will give quick answers to this question: Is this patient cancer?

The tests in the lab have shown that scientists can distinguish normal DNA from DNA by looking at the color change in the gold particle solution, which appears in the naked eye in a few minutes.

"This test can be done with other simple tests, and can be a powerful diagnostic tool that simply can not say that you have cancer, but there is also type and phase," Karscosa said.

Gord Brandy of the Cancer Research UK Manchester Institute said: "This approach represents an exciting step in detecting DNA in blood samples and opens the possibility of general blood-related testing to detect cancer. More clinical studies are needed for a possible clinical evaluation of the entire clinical system."


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