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He gives details of the limits of the therapy he wants to destroy the body's HIV reservoirs



Published 1/22/2016 11:45:29CET

Barcelona, ​​Jan. 22 (Europe Press) –

Researchers at the Institute for AIDS Research, Irisikaix researchers have given details of the main limitations of the therapies in the body for the purpose of destroying HIV reservoirs, which are secreted in confidential cells that the immune system is not diagnosed and therefore it is impossible to destroy.

& # 39; Frontiers in Immunology & # 39; The published work shows the low power of HIV reactive medications, and the insufficient efficiency of the system's cells.
Immune power that must destroy the virus.

Center's scientists – The General Regional Ministry of General and La Saxony established a jointly promoted model that allows it to limit obstacles to the efficacy of the removal of water treatment.

For the first time, they identify how the immune system's CD8T cells are associated with the high speed and efficiency of reactive drugs when it comes to the destruction of these active cells.

& # 39; Shock & Kill & # 39;

This work & # 39; shock and destroy & # 39; , Which focuses on the limitations of the current therapeutic strategies, which are aimed at creating these reservoirs by awakening inactive cells and then eliminating them.

For this reason, the so called latency reactive Drugs (LRF) is used, which re-activates the infected cells so that it can be destroyed by CD8T and other cellular types of immune system, as well as by medication and other removal strategies.

Although many medical studies have shown that FRL is capable of retracting latency, reduction in the viral reservoir size in patients could not be detected till date.

Unnecessary power

The work concludes that the main obstacles to the removal are the insufficient power of active agents, which fails to make all the cells visible.
Infected, and lacking the immune system of CD8 T cells, responsible for recognizing and removing this.

This immune system is associated with high expression of immune receptors in the study, which is responsible for regulating immunological activation and whose expression is enhanced.
Chronic Infection Procedures


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