New experimental strategy developed by researchers at the Massachusetts Institute of Technology (MIT) in Cambridge (United States)Allows the joints against the osteoarthritis to access and reproduce the inner cartilage of the joints. Rats test, advance, guess A step forward in seeking treatment for the slow progress of this disease, for which there is no solution today.
Due to old age or injuries in arthrosis, progressive degeneration in the cartilage of the joints occurs. This affects pathology 300 million people The whole world and it does not have reverse gear, because cartilage is a tissue that can not be reproduced. While therapies that can reduce the symptoms of arthrosis, today there is no cure that can slow down its progress. When pharmacological treatment is not enough, patients may choose to perform the operation to enter prostheses in the affected joint, a process that is not risk or decisive.
One of the main obstacles is that it is very difficult to access the treatment of medication. Most joints are removed before they can be affected or they can not penetrate into the contractile, where the cells that produce them – condoscots – are found, so that they can not function.
Researchers under MIT have sought a strategy to overcome this obstacle. They have designed a nanocarse: an atom that acts as a vehicle and is able to get into the comodilage and bring a drug into droid. This piazone consists of a circular portion, in which the drug builds, the positive electrical charge is combined with branch-like structures and the PEG.
Since then There is a negative charge in cartilage, The nanocarrier's positive charge adheres to the tissues. On the other hand, the PEG allows him to break from cartilage and reach the condos.
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According to a report from the journal Science Transitional Medicine, the scientists added INF-1 to the nanocarrier, which encourages the production and production of cartilage and the development and development of chandracets. To check the strategy, they did a nanocerge injection with the drug In the knee joints with osteoarthritis from injury. In this treatment, the appearance of cartilage degradation, inflammation and osteoarthritis related bone change decreased. Compared with IGF-1 injections alone, the combination of nanocarrier increases the life of the drug in half a half. Also, this It has been in an effective concentration for 30 days in the infestation, so potentially baywake or monthly injections will be enough.
On the other hand, researchers In cows therapy, it has been investigated that this strategy allows the drug to pass through the thickness of these tissues by up to one millimeter., A similar scale of human joints.
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Nanoocars can be loaded with other medicines and accepted for the treatment of osteoarthritis associated with aging. Before starting testing on the people, the authors should try it on other larger animals, which in turn increases the joints like humans.
"It is a very interesting study that does not participate in research," says Josep Varghese, president of the International Osteoarthritis Foundation (OAFI). According to Vergee, If it is applied to people and was effective in rats, a new strategy can improve the quality of life of patients, because one or two injections will be sufficient every month. Vergys says, "It may take four to eight years before the medical professional becomes available commercially, but" you have to check whether you should confirm in clinical trials. "
Source: La Vangardia