Oxford University scientists have investigated that Mexican fish has the ability to reproduce their heart and find that The abnormal capacity of genes that make up is also present in humans. Researchers say the results of a new study published in the journal Cell Reports, hope for a positive change in patients' lives, suffer from a heart attack.
To reach this conclusion, the team of scientists – led by Professor Matilda Momstigg – studied two types of tetra-Mexican fish. This Astyanax Mexicans, who live in the rivers And it shows a beautiful color, it can heal your own heart, while the other subspecies, which Spring from the cave Pachine and it's known as & # 39; Blind Tatra & # 39;, It has not only lost its color and vision, the features do not serve it in the dark of cave, but it does not have the ability to reproduce the heart tissues.
In the study, researchers They compare the genetic profile of two types of tetra-fish And identified three genomes of their genome that are related to the ability to reproduce the damaged heart tissues.
Then, by comparing the behavior of these genes in the river Tatra and in cardiac damage after the cardiac damage, scientists noticed that only the first two genes have increased in activity, lrrc10 (also present in humans) and cavolin.
In previous research in mice, it has also been demonstrated that lrrc10 is associated with the condition of the heart, which is called dated cardioopause, in which the heart grows in greater proportion and can not pump the blood for a long time. The results of subsequent studies suggest that lrrc10 plays an important role in the contraction and expansion of the heart cells.
To confirm that this gene is also associated with the recovery of damaged heart tissue, researchers of the new study have turned to zebrafish, as well as other species of fresh water, such as tetra-fish, the ability to reproduce heart tissues. If necessary Scientists blocked the expression of LRC 10 gene in zebrafish, which was unable to effectively include them with the loss of heart.
In the future, the research team wants to know more about the mechanisms for recovery of these tissues and the use of those knowledge in people who face problems with this organ, such as heart failure.