Wednesday , January 27 2021

USAL researchers worked in search of molecules with antibiotic activity



Salmanca, Dec 4 (Europe Press) –

Researchers from the Metabolic Engineering Group of Salamanca University (USAL) have collaborated in international studies to describe specific pathogensic mechanisms of some pathogenic bacteria.

North American Journal Proceedings of the National Academy of Sciences (PNS) of the United States of America published this international work, in which USAT metabolic engineering groups participate and open new paths in search of atoms with antibiotic activity.

USL According to a report by Europa Press, "The work shows how bacteria use bacterial metabolism methods in the absence of oxygen, which is considered to be very special from living organisms such as moss and vegetation."

In this sense, its promoters by USLA have explained that live humans produce the energy needed by food by "a very complex network of biochemical reactions of food, biochemistry".

Metabolism processes within cells are the basis of life on the molecular scale, from which, in other important activities, there is a necessary energy to be raised, raised or reproduced.

There are different types of metabolic reactions and, keeping in mind their relevance, a "large majority" of these processes has been studied and has been described "widely" in recent decades, they have continued.

However, some creatures are still able to find new varieties of metabolic processes and, in this context, Salamanca University has helped in the search of "new and specialized metabolic method of some pathogenic organisms" by the Metabolic Engineering Group. "According to Jose Luis Revuelta Dowell, professor of microbiology and genetics at Salamanca University and Group Director, Group of Companies.

Release

International work, integrated by the Institute of Natural Resources and Selamanka's Agrobiology (CSIC) Scientific Monica Balceira, has been published by the North American Journal Proceedings of the National Academy of Sciences of the United States of America (P.NAS).

From a scientific perspective, the discovery is a "great interest", given that it is the first evidence that "some bacteria that live in an atmosphere lacking in oxygen, where they can not come in the light, use metabolic mechanisms, which I have thought to be so far as photosynthesis Living animals were like mosses and plants, "the researchers explained.

The International Union has studied novel proteins that exist, in particular, in some aerobic bacteria, which are bacteria that live in the atmosphere which lack oxygen.

These proteins are a separate chimney of two distinct proteins, which usually appear in different metabolic pathways: NADFH-dependent theorexics reductase (NTR), which is present in all cognitive organisms; And Feradoxin-dependent Theorrexine reductase (FTR), which is unique to photosynthetic biology.

The resulting protein, the pharodoxine-dependent Flavin-Theodorodin reductase (FFRR), is "special" because it contains the "unprecedented" mixture of the efficiency of two early proteins.

On the one hand, FATR interacts with Feradoxin as it does and, on the other hand, it uses the same bonding module as the NTR in Flavin Cofactor. As a result of this combination, "A new protein is produced with unique properties that are described in detail and for the first time in an article collected by PNS," it underlines.

New roads

From the biomedical point of view, the study presents "more likely, if possible" because these proteins contain "extremely dangerous" pathogens in some of the bacteria, including clostridium difficile, clostridium botulinum and clostridium. Titania has suggested by USLA due to pseudomembronous colitis, botulism and tetanus disease, respectively.

Therefore, this discovery opens the doors for the development of new approaches to the discovery of molecules with antibiotic activity, due to the increased emergence of resistant and multistorstant bacteria, due to the rapid conditions in recent years, one of the most pressing public health problems. Years due to the abusive use of antibiotics "

International Consortium

In other actions, "basic" was to carry out the work, getting a three-dimensional structure of protein on the atomic resolution through high-energy X-ray dissolution experiments produced in ALBA (Barcelona) and Diamond (Oxford) synchrotons.

A three-dimensional structure that is the work of Salmanka scientists, Jose Luis Revalta of the Metabolic Engineering Group of the Genetic Department of Reuben Martinez-Buu, David Fernandez-Jesell and José Luis Revalta, Microbiology and Salamanca University and has been implemented. Responsible for the study, CSIC researcher Monica Balceira (IRNASSA), Cellular Institute's Jose Maria de Pérea and Cancer (Molecular Biology of Cancer (USAL-CSIC) and Berkeley (in collaboration with California universities in Berkeley (United States)) and Newchtel (Switzerland).


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