Sunday , August 1 2021

The block block "Hormone Hormone" activates the defense cells



For decades, researchers have been trying to find a wide variety of immune systems. Insights in recent years Cancer Therapy paved the way for a new age. If an immune system is actively involved, the body can resist cancer cells and other colonies. Cancer Therapy is revolutionary for this approach, the Nobel Prize for Medicine of the Year. An international research team now headed by Vinnesa IMBA and Clifford Wolfe of Boston Children's Hospital in Harvard provides new insights on immunization vaccinations that offer a variety of medical applications that offer a variety of medical applications.

Immune keypad

What's amazing about this is that the immune system of the body known as T-cells is activated through a molecule that plays an important role in the metabolism of our nervous system. The need for tetrahydrobiopoeeter or BH4 is not required for the production of "joy hormone" serotonin and dopamine. "It is interesting to know that a genuine known factor in nadiobiology is to discover that T Cell Immune plays this important role," says Joseph Peninger, the founder and director of IMA's founder, current author of the current publication. "This new approach has been different from the immune check points that were previously associated with both the totally different systems of the body. + In addition, the treatment options are widespread: self-degrading diseases, asthma, from allergies to cancer!"

BH4 contains many chemical compounds in the body. Since the 1980s, people who have less or anemia of iron can often lead to immune problems, but one can not explain this relationship. Now we know why: Electric power plants of cells – BH4 controls the growth of the cell cells in our immune system through the control of iron bulbs and motes.

T cells invader our bodies, recognize the pathogens or cells that can be eradicated. In such encounters, T cells become active, aggravate, aggressive, and go to any kind of aggressive mode to target cancer cells. Often a problem: Wrong active cells are resistant to the body's own cells – this occurs in allergic reactions involving autonomic diseases, such as ulceration, asthma, multiple sclerosis, arthritis, or some skin diseases.

Haiti: Clinical use against auto anemia, allergies and cancers

"In addition to infectious diseases around the world has become allergic to reagapratireadhavyavasthakalum around the world. Treatments urgently needed. Here is our discovery is very useful. Such self-inhibiting T cells and tissues healthy and preventing BH4 is on the Prevention of long-term inflammation that destroys or prevents the creation , "Shan said kreanin, also post-doctoral collaborator Shane natural kreanin said the first author of the current publication IMBA. In addition to Clifford Wolfe and Kai Jonesson at Boston Children's Hospital in Harvard, Max Planck Institute for Medical Research at Hydelberg developed a novel drug QH 385. This prevents BH4 and produces "immune" cells in violent malpractices. The first clinical trials are in the tip.

BH4 is the main candidate for the prevention of future cancer prevention. T cells are active and are resistant to cancer. Research on mice has found that BH4 can help with cellular cells to achieve tumor goals. In addition, Kynurenine, BH4 can prevent a molecule that can inhibit immune function. The weight of BH4 leads to t cell cell growth.

"Knowledge of new relationships in biology and infection is particularly valuable because applications are very effective, and our immune systems can be controlled by the known molecules from neurobiology, and new applications against self-immune diseases, asthma, cancer, and immunity," says Shine Crane To "If the nervous system and the immune system have found the relationship between different biological systems in the body, you can sometimes do amazing discoveries." In the past, the team surrounding Joseph Peninger team, for example using the RANKL signaling pathway, successfully bundled between the metabolism and the hormone system. The drug, which is responsible for breast cancer, is the treatment of Denoseob range.

Original publication:
"Metabolite BH4 Auto regulates the flow of auto seminalism and cancers", Cronin et al. Nature, 2018, DOI: 10.1038 / s41586-018-0701-2

This research project is supported by the following institutions: IMBA – Austrian Academy of Sciences Institute of Molecular Sciences, Neurobiology, Harvard Medical School, Boston, USA; Boston, MA USA, Ludwig Boltzmann Institute for Molecular Medicine, University Medical Center of Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Maine, Germany, Internal Medicine Section II (and infectious), Kirby Neurobiology Center, Kirby Neurobiology Center, Boston Children's Hospital, Austria, Institute of Chemical Sciences and Engineering, Institute of Bioin Engineering, National Center of Competence in Research (NCRR) in Chemical Biology, Ico Polytechnic FDreal Day Lausanne (EPFL), Lausanne, Switzerland, Economics, Rheumatology, Neomology , Oxford University in UK, Wellcome Trust Center for Human Genetics, Roza The University of Oxford, UK, Gastroenterology and Liver Center Division, the Department of Medicine of the Israeli Department of Israel and the Israeli Deaconos Medical Center (BDMC) Harvard Medical School (HMS), Harvard University, Boston, MA, USA, Laboux, Biokoquia Department, Federal University of Santa Catarina, Florianopolis, SC, Brazil Gill. Information of neurons in the control of merrabealisattinre Eye Research Institute of Molecular Pathology, MP, Max Planck Institute for merrabealaji Research, Cologne, Germany, Department of neurosciences, of the Research Center of the permitted de Quebec – University Lawal, kyusi of Quebec, Canada, the Department of the Institute karealins'ska , Department of Medicine, Seoul, Center for Molecular Medicine, University Hospital karealins'ska solo, Stockholm, Sweden, n'yureasarjari Department, Johns Hopkins School of Medicine, Baltimore, USA Apertain Biologics AG, Vienna, Austria, Quercet Medicin, 400 Techno Square, Cambridge, USA, Anesthesia Department, Harvard Medical School, Boston, USA; Boston Children's Hospital, Boston, USA, Pharmaceutical and Physiology Department, Montreal University de Montréal, QC, Canada, Max Planck Institute for Medical Research, Chemical Biology Section, Hedelburg, Germany

Scientific contact:
Max in in Mehul Blender
Senior Communications Manager
IMBA – Institute of Molecular Biotechnology GmbH
Dr Borg Gass 3, 1030 Vienna
M: +43 664 808473828
E .: [email protected]
The United Nations Observer

Original publication:
"Metabolite BH4 Auto regulates the flow of auto seminalism and cancers", Cronin et al. Nature, 2018, DOI: 10.1038 / s41586-018-0701-2

idw 2018/11


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