To develop, cancer cells can alter their epigenetic makeup to become resistant to drugs and other forms of treatment, found a team of Singaporean scientists.
In a study published by Nature Communications on November 22, the team of Science, Technology and Research Agency (A * Star) Gnome Institute of Singapore (GIS) also said that they target cancer development and discover new approaches to cancer treatment. Cells
These approaches prevent or delay cancer progression in the therapeutic / metastatic disease, said the organization in a press release.
In their study, scientists found that cancer cells are regularly developed under the pressure of the choice of standard-care medicines.
Survival strategies adopted by nodes include "dead play" by turning on inactivity and by activating resistant or metastasic-related genes.
"A better understanding of these mechanisms provides opportunities to target these processes that will help stop or delay the spread of cancer," GIS said.
Traditionally, cancer treatment focuses primarily on eliminating cancer cells by high doses of chemotherapy. But it is difficult when cancer cells seem to be comfortable to stay alive.
By using single-cell genomics and patient-ancillary primary cell (PDP) models to identify different conditions for cancer cells to be resistant or metastatic, scientists have noted that in some patients, cancer cells multiply even though they are treating with the amount of high infections. .
The theory is that these cells themselves were switching to the treatment to make stem cell factors drug-resistant.
"Cancer cells behave like chameleons, they change cell behaviors to eliminate genetic expression and drug treatment. Our understanding of tumor evolution and our ability to predict the next evolutionary phase of cancer can serve as a way to manage therapies in the clinic , "The first author of GIS study and research associate, Dr. Ankur Sharma said.
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Study and GIS group leader Dr. Ramanuj Dasgupta added: "Like the game of a wake-e-mole, cancer cells have a long history of finding alternative ways to avoid treatment. Tumor aims to evolve evolution, aims to prevent our goal or delay its development, and at the same time, Avoid the severe effects of excessive treatment. "
In this report, BRD4 gene has also been identified as a key molecule for resistance. The drug known to block BRD4 activity after the immune cells was treated with Jacqua 1, resulting in nausea or delay of drug-resistance in the tumor cells.
- A * Star's Gnome Institute of Singapore
Professor William Hawang, a medical director of the National Cancer Center Singapore (NCCS), said that finding can help clinical practitioners identify patients with cancer who are at the highest risk of treatment-resistant relapses. Good treatment options are offered when the patient is in trouble again.
Professor Huang added that NCCS wants to translate conclusions into clinical practice in the near future.
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