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Bacteria make antibiotics more susceptible to cranberry extracts

Known for its high content of vitamin C and antioxidants, Cranberry regularly uses regularly to fight bacteria and pests responsible for urinary tract infection. But this little Barry Tart does not yet declare all its properties.

A new work conducted at McGill University and the National Institute of Scientific Research in Montreal (INRS) and published in the journal Advanced Science Only it has shown that it can play a decisive role in the fight against bacteria that resist the most powerful antibiotic therapy.

Process in two actions

According to the World Health Organization (WHO), "global public health problems" have antibiotic resistance. The reason is that there is more use of antibiotics in medicine and agriculture, which spread bacterial resistance around the world. In 2014, a report on antibiotic resistance was predicted that by 2050, antimicrobial-resistant infections can be a major cause of death worldwide, which causes 10 million deaths per year.

Based on this horrible report, the authors of the study decided to check Barrio's resistance known to prevent the development of immune pests with crates made from crayberries. Three bacteria were selected: Proteus Mirabilis, Pseudomonas aruginas And Escherichia coli, Responsible for urinary tract infection, pneumonia and gastroenteritis.

The results show that low levels of cranberry extracts also increase bacterial sensitivity in antibiotics. Two actions were seen. First, molecules made from cranberry make the bacterial cell wall more favorable in antibiotics. Secondly, the method used by bacteria in order to remove antibiotics from Cranberry extract has been blocked. As a result, antibiotics can penetrate more easily and bacteria tend to be more difficult to relieve them, so this drug is effective on low doses.

"Generally, when we treat bacterium with antibiotic in the laboratory, it becomes resistant over time," said McGill's chemical engineering professor Nathalie Tufhenky and the main author of the study. "But when we acted together with bacteria with antibiotic and cranberry extracts, no resistance was developed, we were very surprised and viewed it as an important opportunity."

Hope in the fight against antimycrobial resistance

Cranberry extracts on bacteria are produced by molecules called prananthocyanidas. "There are many types of pranthosanides and they can work together to achieve this result." We have to do more research in order to determine who is most active in the correlation with antibiotics, Professor Erik Daisell, microbiology in the intersection. " And co-authors of the work.

Hence, researchers will then experiment with new animal experiments to clearly identify atoms. If the results are confirmed, some classes of antibiotics can be used in high levels of reactive immersion using cranberry extracts to increase their capacity. "We look forward to continuing this research," says Nathalie Tufanekzi. "Our hope is to reduce the amount of antibiotics required in human and veterinary therapy as part of a fight against antibiotic resistance."

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