Saturday , January 23 2021

Exercise hormones can help in the fight of Alzheimer's, research suggests

Hormones released during exercise can protect the brain against Alzheimer's disease, research suggests.

Irisine is a messenger protein produced by muscle tissue that moves around the body in the blood stream.

New evidence suggests that it can be behind the known positive effects on the exercise of taking exercise.

US And Brazilian scientists have found low levels of hormone in the brain of Alzheimer's patients compared to healthy people. The same was true for preceding proteins, from which Irisin is produced, F.D.D.C. 5.

In genetically engineered mice tests, scientists have cut off irisin and encouraged learning and memory impairment.

They could reverse the effects by restoring the hormone.

When Irisin signaling was blocked in the mice with alzheimer's mice version, the benefits of the physical exercise brain were lost.

Research under the leadership of Dr. Fernáne de Félis of Brazilian Federal University of Rio de Janeiro, has been reported in the journal Nature Medicine.

Scientists have said that the base irradiation can provide a "novel strategy" to prevent cognitive impairment in patients with Alzheimer's disease, either by medication or by exercise.

They wrote: "Our results show that FDDC5 / Irisine levels are reduced in human AD (Alzheimer's Disease) brain and CSF (Cerebospinal fluid) and FD mouse models, and that brain or peripheral fdc 5 / Irisin stimulates levels that reduce the loss of synaptic and memory. In AD mouse models. "

The team adds, as Irisin enters the brain and needs more research to understand how it interacts with it.

British experts noted that despite research, promising, at the very beginning stage.

Dr. Rosa Sanko said from charity Alzheimer Research UK, "We know that physical activity is linked to health in a superior brain, and this research focuses on a biologist mechanism that can contribute to this beneficial effect.

"These interesting findings present a new avenue for future research, which can help us better understand the way in which brain programs can be targeted to provide the most benefits to brain health.

"Many people are at high risk of dementia or dementia, who have health conditions to make regular exercise more difficult.

"Drugs designed to target identified hormones in this research can potentially give some benefits to physical activity to people who may be less capable of exercising."

Head of research at Alzheimer's Society Charity James Peckett said: "The study was only in the mice, it adds to the increasing evidence of relationships like lifestyle factors, physical fitness and dementia. This is a promising avenue for further research and possible new remedies."

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