A new treatment approach for broken teeth
Tooth decay is no longer reversible, just as a broken tooth cannot regenerate. Today's dentistry compensates for such damage through artificial materials. In mice, however, this looks very different. If your anterior teeth hurt them they can move again. The international research team has now explained the mechanism responsible for this regeneration. Researchers believe that it is possible for humans to use this ability as well.
An international team of scientists, assisted by the Dresden University of Technology, found a new type of tooth repair based on the regenerative powers of mouse teeth. The research group identified the genetic processes that lead to tooth development. This opens up a whole new way in dentistry that can eliminate tooth decay and other damage. The results of the study were recently presented in the famous journal "Nature Communications."
Teeth are made of cells
Stem cells are cells that can mutate into specific cells. This principle applies to all cell types in the body, including teeth. While human teeth are not intended for regrowth, this is common in some species such as mice and sharks. But how does one decide if a tooth has this ability? This puzzle has now been solved in international studies.
How can mouse teeth revolutionize dentistry?
The research team found specialized cells in the anterior teeth of mice responsible for the formation of dentin. Dentin is hard tissue that powers teeth. In mice, these cells cause the anterior tooth to rearrange when worn. Researchers discovered that mouse tooth cells are called mesenchymal stromal cells. When these cells are activated, it sends a signal to the mother cells of the tissues triggering the new production of cells.
The gene controls the healing process
According to the study, the DLk1 gene is involved in this process. This same gene also controls tissue regeneration in the healing process. According to the research team's report, activation of this gene is a potential approach for human tooth repair, such as cartilage, chalk tooth and tooth fracture. It is possible to accelerate wound healing by this gene. However, this must be validated in the first clinical trial. If the concept is confirmed in humans, human teeth may also be regenerated soon. (VB)
Graduate Editor (FH) Volker Blessec
- Dresden University of Technology: Are dental repairs completely different? Scientists find a mechanism that can replace future dentistry (call: 09.08.2019), tu-dresden.de
- Walker. Gemma Victoria / Zhuang, Hang / Hu, Bing / et al .: Transit Amplifying Cells Mouse Incisor Mesenchymal Stem Cell Activation, Nature Communications, 2019, integrates nature.com.