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Ebola is now curable, says new clinical trial at DBC



In August Gust 2018, Ebola erupted in the Democratic Republic of Congo's North Kiev province. That soon.33. 81 million people were dispersed elsewhere in the country, many of whom are besieged in combat by carrying valuable DRC minerals. By April, the outbreak had become the worst record ever, and by June it had killed at least 1,357 Kongis.

But a recent clinical trial that compared the efficacy of four Ebola treatments brings good news.

"From now on, we will not say that Ebola is incurable," said Jean-Jack Muyembe, director-general of the Institut National de Richer Biomé Dicle, who oversees the hearing. "These advances will help save the lives of thousands."

In November 2018, DRC doctors began assigning Ebola patients to one of four treatments: antiviral drug called remidivir, or one of three drugs made from monoclonal antibodies, a cluster of immune cells cloned from the parent cell. Zmap – one of three drugs using monoclonal antibodies – has long been considered the most effective treatment for Ebola. Patients who took it in recent clinical trials had an overall mortality rate of 49 percent.

But two other drugs of the same class – a cocktail of monoclonal antibodies manufactured by a company called Regeneron and an antibody called MAB 114 – created by the National Institutes of Allergy and Vaccine Research Center for Infectious Diseases were more effective. 29 and 34 percent, respectively. These drugs were developed by giving rats Ebola, and then using antibodies produced by rats. Then the scientists .The scientists tweaked those rat antibodies so that the human body could accept them. Both drugs will now be offered in each DRC treatment center.

Monoclonal antibodies based drugs were particularly successful in curing Ebola when patients were taken immediately after they became ill, reducing the dose of regenerone by only a few percent. But one problem is that most Ebola patients in the DRC wait an average of four days before coming to the hospital, which reduces survival difficulty and increases the odds of transmitting the disease – to people around – through body fluids.

But health experts are optimistic about new drugs.

"The more we learn about these two treatments, and how that exposure can supplement public health responses, including health and vaccinations, we can turn Ebola from a deadly disease into a preventable and preventable disease," said Jeremy Ferrer, World Health. Said, co-chair of the organization's Ebola therapeutic group The GuardianGeneral Chat Chat Lounge "We will never get rid of Ebola but we will stop turning into major national and regional epidemics of this outbreak."


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