Tuesday , February 7 2023

Explore & # 39; Shock & # 39; by researchers. Detects that ALS-diseased neurons show incredible elasticity if given glucose


According to a new study, increased glucose, converted into energy, can improve the mobility and long life of people with ALS.

Therapists have long known that people with ALS experience a change in their metabolism, which often leads to faster weight loss in excessive cycles, according to the research team led by Arizona.

People with ALS use more power without rest, compared to those unhealthy individuals, when they once struggled to use glucose effectively, then the body needed a specific component to make more energy. Experts do not know what happens in the patient's cells and how to reduce the problem.

The study's leading author Ernesto Manzo said, "This project is a way to analyze those details." Life, As "true traumatic"

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Studies have shown that when neurons affected by ALS are given more glucose, they turn the source of energy into energy. With those energy, they can last longer and do more work. Increasing glucose delivery in sales can be one way to meet the high energy demand of ALS patients.

"These neurons were getting some relief by breaking the glucose and getting more cellular energy," said Amenzo.

ALS is almost always a progressive disease, eventually eliminating the ability of patients to walk, speak, and breathe. The average life expectancy of the ALS patient at the time of diagnosis is two to five years.

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Prior studies on metabolism in ALS patients have focused primarily on what happens at the whole body level, Daniela Zernescu, a professor of molecular and cellular biology professor and a senior author on the study, explained.

Researchers have noted that the lobes of the fruit of the ALS-affected fruit fly under the microscope. The picture is a nerve cord, which expresses the green glacose transporter, that resides with green-scarred motor neurons. Neurotransmitter release areas appear red, while the muscles appear blue. (Courtesy of Zarnescu Lab)

Zarnescu said, "The fact is that we've covered the return system, I'm surprised." "These desperate, degenerative neurons exhibit incredible elasticity. An example of how attractive cells are in dealing with stress."

Zernescu said that the novelty of these findings is partly in fact that ALS patients have a poor understanding of metabolism.

"Difficult to participate due to limited access to the nervous system," she said.

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Because scientists can not absorb neurons from the brain without causing unreliable damage to the patient, researchers have used fruit flies as models.

"Fruit flies teach us a lot about human diseases," said Emmano.

In the lab, he and Zernescu used high powered microscope to observe the motor neurons of fruit flies in their Larkwell state, which had to pay close attention to the glucose that provided more glucose.

They found that when they increase the amount of glucose, motor neurons live longer and move more effectively. When the researchers removed glucose from the neurons, the fruit fly larva slowly moved.

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Their findings were consistent with a pilot clinical trial, in which there was a possible intervention for ALS patients with a high carbohydrate diet gross metabolic disfusion.

Zernescu said that "Our data provides an explanation why those approaches work." "My goal is to explain the idea to clinicians for a bigger medical trial."

Reprinted from Arizona University

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