Saturday , January 16 2021

Infant research recognizes biomarkers to find brain injury in newborns – Irish Tech News



The lack of oxygen in the brain at birth affects approximately 200 children per year in Ireland and globally causes death or disability in more than 2 million infants per year. This condition, condition known as hypoxic ischemic encephalopathy (HIV), causes brain injury due to lack of oxygen and can cause newborns with permanent neurological damage or cerebral palsy. Finding it in the newborn can be difficult; Early intervention and treatment are important for improving results and reducing the impact and intensity of brain damage.

Researchers from the dedicated embryo and infant research center of Ireland, University College, Cork, has identified two biological signals in Cork, which can be used to detect birth-related brain injury. This blood is found in biomarkers ambulatory cord, which is available in newborn babies. Can provide an initial search method for Early intervention in newborn brain injury is critical so that successful brain cooling therapy can be started to reduce brain injury and improve results.

The American Medical Association (JAMA), published this week in the journal Neurology, approved the involvement of two MicroNNA in HIE. MicronsNS is a small part of the genetic code that can control genetic expression and protein production in the cell. They are found throughout the body, and infant researchers have found them immensely in coconut's blood, and newborns have been significantly reduced with HIE. They can give the first indication that there is significant injury and help doctors decide which infants move to the cooling center for treatment.

Principal Investigator of INFant and UCC professor Diedere Murray recently led research research into the field of HIV and Perinatal Afexia, published in December (December 28, 2018).

"The results of this preliminary study are very promising: In two different groups, we are seeing the same pattern in two countries. The next task will be to automate this analysis so that it can be done faster on the cotide. Whether or not there is an important role in the injury cascade of high. It is a small molecule code that is used to control the production of protein in the cell. Some of these proteins may have an important role. We have now funded by the Irish Research Council to check whether changes in micragnation can reduce or prevent brain injury. There is still a lot of work to do and we We hope to advance this important research. "Professor Diedre Murray of Principal Investigator of Infant The View.

This study was supported by funding by the Health Research Board and the National Children's Research Center, and resulted in approximately 10 years of study in the area of ​​early brain injury.

Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the main causes of neurologic disabilities around the world. Within narrow therapeutic period, it is difficult to identify suitable infants for therapeutic hypothermia (brain cooling), and so far, there is no strong biochemical marker available for medical practitioners. This research is capable of identifying microns in the Nimbil cord and this is a very important step in early diagnosis and treatment of affected children due to lack of oxygen in the brain.

Infants from Ireland have participated in research, in which blood samples of coconut cord blood from 170 newborns of Ireland and Sweden have been collected and analyzed for many years.


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